The Journal of Medical Sciences

Register      Login

VOLUME 3 , ISSUE 1 ( January-March, 2017 ) > List of Articles

RESEARCH ARTICLE

Study of Association between Microalbuminuria and Microvascular Complications in Type II Diabetes Mellitus Patients in RajaRajeswari Medical College and Hospital, Karnataka

N Bhavya, V Ajith Kumar

DOI: 10.5005/jp-journals-10045-0046

License: NA

Published Online: 01-12-2017

Copyright Statement:  NA


Abstract

Introduction

India is claimed to be the diabetes capital of the world. Many studies had proven that persistent hyperglycemia and associated metabolic syndrome features like hypertension, dyslipidemia, and obesity contribute to the development of vascular complications. The risk of chronic complications increases as a function of the duration of hyperglycemia; they usually become apparent in the second decade of hyperglycemia. Since type II diabetes mellitus (DM) often has a long asymptomatic period of hyperglycemia, many individuals with type II DM have complications at the time of diagnosis. The vascular complications of DM are subdivided into microvascular (retinopathy, neuropathy, nephropathy) and macrovascular (coronary artery disease, peripheral arterial disease, cerebro-vascular disease) complications. The present study aims to study the occurrence of microalbuminuria in patients with type II DM and note its association with the duration of diabetes since diagnosis and microvascular complications of DM.

Study design

Prospective observational study.

Materials and methods

The study is a clinical, prospective, and observational study of 100 type II diabetics attending the medicine department outpatient/inpatient of RajaRajeswari Medical College & Hospital, Bengaluru, Karnataka, India, who form the subjects for the study conducted from August 2015 to July 2016 (12 months) and who matched the inclusion criteria.

Data were collected after obtaining informed/written consent from patient. After detailed history, detailed clinical examination, and general physical and systemic examinations, fundoscopy was carried out and relevant laboratory investigations were done.

Results and conclusion

The overall occurrence of microalbuminuria was 38%. The occurrence of microalbuminuria showed a direct relationship with increasing age (p = 0.053) and increasing duration of diabetes since diagnosis. A hemoglobin (Hb)A1c value above 7% is associated with 50% or higher incidence of microalbuminuria (p = 0.018). Patients with a body mass index of more than 25kg/m2 have increased risk of developing type II DM and significant increase in microalbuminuria. The incidence of microalbuminuria is significantly associated with

How to cite this article

Bhavya N, Kumar VA. A Study of Association between Microalbuminuria and Microvascular Complications in Type II Diabetes Mellitus Patients in RajaRajeswari Medical College and Hospital, Karnataka. J Med Sci 2017;3(1):6-10.


PDF Share
  1. Diabetic nephropathy. In: Brenner, Rector, editors. The kidney. 4th ed. Vol. 2. Philadelphia: W.B. Saunders Company: 1991. p. 1695-1719.
  2. ; Bornett, D.; Levine, R. The history of diabetes. In: Kahn ER, Weir GC, editors. Joslin's diabetes mellitus. New Delhi: B.I. Waverly: 1994. p. 1-13.
  3. ; Flisa, D.; Siebers, M. Diabetic nephropathy. In: Massry SG, Glassock RJ, editors. Text book of nephrology. 3rd ed. Vol. 1. Williams & Wilkins 1995.
  4. Photocoagulation for diabetic macular edema. Report No. 4. Int Ophthalmol Clin 1987 Winter;27(4:)265-272.
  5. Diagnosis and classification of diabetes mellitus. Diabetes Care 2006 Jan;29(Suppl 1): S43-S48.
  6. Clinical practice recommendations. Am Diabet Assoc 2002 Jan;25(Suppl 1):S85-S89.
  7. Microalbuminuria in non insulin dependent diabetes and essential hypertension: a marker of severe disease. J Assoc Physicians India 1994;42(10):771-774.
  8. Microalbuminuria in non insulin dependent diabetes mellitus. J Assoc Physicians India 1999;47(6):596-601.
  9. Microalbuminuria in normotensive non insulin dependent diabetic subjects – associations and predictions. J Diab Assoc India 1997;37(2):30-36.
  10. Association of microalbuminuria with carotid intima media thickness and coronary artery disease – a cross sectional study in Western India. J Assoc Physicians India 2002 Sep;50(9:)1124-1129.
  11. Microvascular complications at time of diagnosis of type 2 diabetes are similar among diabetic patients detected by targeted screening and patients newly diagnosed in general practice. The hoorn screening study. Diabetes Care 2003 Sep;26(9:)2604-2608.
  12. Long term complications in newly diagnosed Srilankan patients with type-2 DM. QJM 1998 Jun;91(6:)439-443.
  13. Symptoms, signs and complications in newly diagnosed type 2 diabetic patients, and their relationship to glycaemia, blood pressure and weight, Denmark. 2004. Diabetolgia 2005 Feb;48(2);210-214.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.