Introduction: Serum protein electrophoresis (SPEP) is a widely used biochemical test for diagnosing and monitoring plasma cell neoplasms, and it is frequently used in conjunction with immunofixation electrophoresis (IFE).
Aims: To elaborate on the patterns of SPEP and IFE in a tertiary care hospital in eastern India.
Materials and methods: A total of 455 cases satisfied the inclusion criteria of the study and were evaluated with SPEP using the Sebia Hydrasys 2 Scan Focusing System. IFE is performed when indicated.
Results: Of the 455 cases, 153 (33.63%) had monoclonal gammopathy, with immunoglobulin G kappa (IgGκ) being the most prevalent monoclonal protein found (47.50%). Multiple myeloma was the most prevalent neoplasm involved in 280 (61.53%) cases.
Conclusion: Serum protein electrophoresis and IFE are widely available and easy-to-administer tests recommended by international guidelines for screening and monitoring therapy of plasma cell neoplasms.
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