"Introduction: Coronavirus 2019 (COVID-19), pandemic has increased mental illnesses. Vaccination was the preferred method of protection and there is sparse knowledge regarding the impact of vaccination on mental health status. Awareness, availability, and accessibility to healthcare vary between urban and rural settings. Aim: This study compared the adherence to COVID-appropriate behavior, psychiatric illnesses, and quality of life (QOL) among post-vaccinated individuals in urban and rural populations. Materials and methods: A comparative cross-sectional study was done on 606 vaccinated individuals of both urban and rural Bengaluru. Data was collected through a self-structured questionnaire which incorporated a sociodemographic profile, depression anxiety, and stress scale (DASS-21), and QOL and was analyzed using Statistical Package for Social Sciences (SPSS) version 23. Results: In both urban and rural population, majority followed COVID-appropriate behaviors. It was found that anxiety was significantly high in the rural, whereas QOL was low in both urban and rural areas. Individuals with high scores on depression, anxiety, and stress (DAS) were found to have a negative correlation with QOL. Conclusion: In addition to vaccination, adhering to COVID-appropriate behavior is necessary to eradicate the disease. Appropriate mental health care should be provided even in the rural setting to address COVID-related anxiety and depression."
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