Olanzapine is a potent second-generation antipsychotic commonly used in the treatment of many psychiatric illnesses. It is considered more potent and has less incidence of extrapyramidal symptoms compared with first-generation antipsychotics. With sedation and weight gain being considered as the most common adverse effects, it has also been reported that peripheral edema is associated with olanzapine therapy, but only a few cases of facial edema have been reported so far. However, a definitive cause and consequence of edema are not established, as it is not commonly encountered in medical practice. As olanzapine is a commonly used atypical antipsychotic, we report a case of bilateral pitting pedal edema and facial edema in a woman with no medical comorbidities after initiating olanzapine therapy. All systemic causes of edema were ruled out, and it was completely resolved after discontinuation of olanzapine.
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