Citation Information :
Reddy N, Benachinmardi K, Sampath S, Anjina L S. Can Glycemic Parameters Predict Causative Pathogen in Diabetic Foot Ulcer?. J Med Sci 2023; 9 (1):10.5005/jp-journals-10045-00225.
"Introduction: About 15% of diabetic patients get affected with a complex and heterogeneous disorder with diabetic foot syndrome (DFS) once in a lifetime. Objectives: To record the pattern of pathogenic infectious agents across various levels of fasting blood glucose (FBS) levels and hemoglobin A1c (HbA1c) in type 2 diabetic foot ulcer patients to determine the better predictor among culture growth and FBS levels. Materials and methods: This is a cross-sectional study at a tertiary healthcare center for the duration of 2 months. Pus from the diabetic foot infection was sent to the microbiology laboratory and processed immediately. Microorganism identification and antibiotic susceptibility testing were carried out as per the standard procedures. At the same time, FBS by spectrophotometric method and HbA1c values [Bio-Rad DIO HbA1c analyzer, by high-performance liquid chromatography (HPLC) method] of all the patients involved in the study were recorded. Results: Maximum patients (81%) had FBS of >126 mg/dL and 58% had HbA1c of ≥10. Gram-negative bacilli (GNB) were 80% and gram-positive cocci (GPC) were 20%. With FBS of <100 mg/dL, culture revealed 50% of Klebsiella spp and 50% of Proteus spp. In FBS of 100–126 mg/dL, P. aeruginosa (50%) was common. In ≥126 mg/dL, along with GNB, GPC was also detected. Conclusion: Fasting blood glucose (FBS) and HbA1c values can be of great help in predicting the organism associated with diabetic foot infections and starting the bacteria-targeted antibiotic therapy to reduce further complications."
Pandey SK, Sharma V. World diabetes day 2018: battling the emerging epidemic of diabetic retinopathy. Indian J Ophthalmol 2018;66(11):1652–1653. DOI: 10.4103/ijo.IJO_1681_18
Anand A, Biswal I, Soni R. K, et al. A clinico-microbiological study of diabetic foot ulcer patients to identify risk factors and their correlation with prognosis in tertiary care hospital in India. IntSurg J 2016;3(2):669–673. DOI: 10.18203/2349-2902.isj20161141
Bengalorkar G, T NK. Culture and sensitivity pattern of micro-organism isolated from diabetic foot infections in a tertiary care hospital. Int J Cur Biomed Phar Res 2011; 1(2):34–40.
Collee JG, Fraser AG, Marmion BP, et al. Mackie and McCartney Practical Medical Microbiology. 14th ed. Churchill Lvingstone: Elsevier; 2008.
Clinical and Laboratory Standards Institute. Performance Standards for Antimicrobial Susceptibility Testing; 23rd Informational Supplement, CLSI Document M100-S23. Wayne PA: Clinical and Laboratory Standards Institute; 2018.
Maitra A. The Endocrine systemIn Kumar V, Abbas AK, Aster JC, Editors. Robins and Cotran Pathologic basis of diseases. South Asia edition. India: Elsevier; 2015.
Manda V, Sreedharan J, Muttappallymyalil J, et al. Foot ulcers and risk factors among diabetic patients visiting Surgery Department in a University Teaching Hospital in Ajman, UAE. Int J Med Public Health 2012;2(3):34–38. DOI: 10.5530/ijmedph.2.3.8
Jain SK, Barman R. Bacteriological profile of diabetic foot ulcer with special reference to drug-resistant strains in a tertiary care center in North-East India. Indian J Endocrinol Metab 2017;21(5):688–694. DOI: 10.4103/ijem.IJEM_546_16
Haldar J, Mukherjee P, Mukhopadhyay S, et al. Isolation of bacteria from diabetic foot ulcers with special reference to anaerobe isolation by simple two-step combustion technique in candle jar. Indian J Med Res 2017;145(1):97–101. DOI: 10.4103/ijmr.IJMR_1436_14.
Lipsky BA, Berendt AR, Cornia PB, et al. 2012 Infectious Diseases Society of America clinical practice guideline for the diagnosis and treatment of diabetic foot infections. Clin Infect Dis 2012;54(12):132–173. DOI: 10.1093/cid/cis346
Citron DM, Goldstein EJ, Merriam CV, et al. Bacteriology of moderate-to-severe diabetic foot infections and in vitro activity of antimicrobial agents. J Clin Microbiol 2007;45(9):2819–2828. DOI: 10.1128/JCM.00551-07