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VOLUME 9 , ISSUE 1-4 ( January-December, 2023 ) > List of Articles


Use of Bisphosphonates in Osteogenesis Imperfecta Leading to Iron Deficiency Anemia and Heart Failure: A Case Report

Jaish George, Nasreen Begum, Dinesh Raghav

Keywords : Anemia, Alendronate, Bisphosphonates, Case report, Genetic mutation

DOI: 10.5005/jp-journals-10045-00224

License: CC BY-NC 4.0

Published Online: 09-10-2023

Copyright Statement:  Copyright © 2023; The Author(s).


Background: Osteogenesis imperfecta (OI) is a group of disorders in which there is a defect in the quantitative and qualitative production of collagen synthesis due to genetic mutations. Case description: We report a case of a 37-year-old dwarf male with OI who presented with severe anemia and cardiac failure. He was on alendronate sodium 70 mg weekly once for the past 2 years. She was treated with transfusions of packed red blood cells, Lasix (loop diuretic), and iron therapy. Conclusion: There is no curative treatment for OI, but bisphosphonate therapy improves the quality of life of the patients. Bisphosphonates reduce bone resorption and thereby fractures. Judicial use should be considered in view of adverse side effects.

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