The Journal of Medical Sciences

Register      Login

VOLUME 6 , ISSUE 3 ( July-September, 2020 ) > List of Articles

CASE REPORT

Peripheral and Facial Edema Associated with Olanzapine: A Case Report

Vishnuvardhan Gopalakrishnan, Sumanth T Parameshwaraiah, Vidhyavathi Malyam, Asha C Sannappa, Suha Riyaz

Keywords : Atypical antipsychotics, Edema, Olanzapine, Side effects

Citation Information : Gopalakrishnan V, Parameshwaraiah ST, Malyam V, Sannappa AC, Riyaz S. Peripheral and Facial Edema Associated with Olanzapine: A Case Report. J Med Sci 2020; 6 (3):47-48.

DOI: 10.5005/jp-journals-10045-00153

License: CC BY-NC 4.0

Published Online: 29-09-2021

Copyright Statement:  Copyright © 2020; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Olanzapine is a potent second-generation antipsychotic commonly used in the treatment of many psychiatric illnesses. It is considered more potent and has less incidence of extrapyramidal symptoms compared with first-generation antipsychotics. With sedation and weight gain being considered as the most common adverse effects, it has also been reported that peripheral edema is associated with olanzapine therapy, but only a few cases of facial edema have been reported so far. However, a definitive cause and consequence of edema are not established, as it is not commonly encountered in medical practice. As olanzapine is a commonly used atypical antipsychotic, we report a case of bilateral pitting pedal edema and facial edema in a woman with no medical comorbidities after initiating olanzapine therapy. All systemic causes of edema were ruled out, and it was completely resolved after discontinuation of olanzapine.


PDF Share
  1. Citrome L, McEvoy JP, Todtenkopf MS, et al. A commentary on the efficacy of olanzapine for the treatment of schizophrenia: the past, present, and future. Neuropsychiat Dis Treat 2019;15:2559–2569. DOI: 10.2147/NDT.S209284.
  2. Nayak V, Chogtu B, Devaramane V, et al. Pedal edema with olanzepine. Indian J Pharmacol 2009;41(1):49–50. DOI: 10.4103/0253-7613.48883.
  3. Ayhan MG, Dagistan AA, Yilmaz G, et al. Periorbital edema induced by olanzapine: a case report. Anadolu Psikiyatri Derg 2017;18(Suppl 1):56–58. DOI: 10.5455/apd.242040.
  4. Umar MU, Abdullahi AT. Self-limiting atypical antipsychotics-induced edema: clinical cases and systematic review. Indian J Psychol Med 2016;38(3):182–188. DOI: 10.4103/0253-7176.183089.
  5. Malhotra M, Shrivastava MK. Facial edema with olanzapine. Gen Hosp Psychiatry 2013;35(6):682.e7–682.e8. DOI: 10.1016/j.genhosppsych.2013.06.012.
  6. Arslan M, Bulut Ü, Naki DD. Olanzapine associated acute peripheral edema and pericardial effusion: a case report. Arch Neuropsychia 2019;56(1):79–81. DOI: 10.29399/npa.22860.
  7. Obayi O. Facial and hand oedema secondary to olanzapine medication in a lady with first episode psychosis: a rare case report. EC Psychol Psychia 2018;7(7):415–419.
  8. Nathan K, Muthukrishnan V, Menon V. Olanzapjne induced tender pitting pretibial edema. J Pharmacother 2015;6(2):114–115.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.