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VOLUME 6 , ISSUE 3 ( July-September, 2020 ) > List of Articles


Peripheral and Facial Edema Associated with Olanzapine: A Case Report

Vishnuvardhan Gopalakrishnan, Sumanth T Parameshwaraiah, Vidhyavathi Malyam, Asha C Sannappa, Suha Riyaz

Keywords : Atypical antipsychotics, Edema, Olanzapine, Side effects

Citation Information : Gopalakrishnan V, Parameshwaraiah ST, Malyam V, Sannappa AC, Riyaz S. Peripheral and Facial Edema Associated with Olanzapine: A Case Report. J Med Sci 2020; 6 (3):47-48.

DOI: 10.5005/jp-journals-10045-00153

License: CC BY-NC 4.0

Published Online: 29-09-2021

Copyright Statement:  Copyright © 2020; The Author(s).


Olanzapine is a potent second-generation antipsychotic commonly used in the treatment of many psychiatric illnesses. It is considered more potent and has less incidence of extrapyramidal symptoms compared with first-generation antipsychotics. With sedation and weight gain being considered as the most common adverse effects, it has also been reported that peripheral edema is associated with olanzapine therapy, but only a few cases of facial edema have been reported so far. However, a definitive cause and consequence of edema are not established, as it is not commonly encountered in medical practice. As olanzapine is a commonly used atypical antipsychotic, we report a case of bilateral pitting pedal edema and facial edema in a woman with no medical comorbidities after initiating olanzapine therapy. All systemic causes of edema were ruled out, and it was completely resolved after discontinuation of olanzapine.

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