The Journal of Medical Sciences

Register      Login

VOLUME 5 , ISSUE 3 ( July-September, 2019 ) > List of Articles


Aripiprazole-induced Diplopia: A Rare Case Report

Manaswini Mullapudi, R Madan, Vishnu Vardhan, M Vidhyavathi

Keywords : Adverse effects, Aripiprazole, Diplopia

DOI: 10.5005/jp-journals-10045-00122

License: CC BY-NC 4.0

Published Online: 15-07-2020

Copyright Statement:  Copyright © 2019; The Author(s).


Background: Aripiprazole is a second-generation antipsychotic (SGA) drug. The commonly reported side effects of aripiprazole are headache, nausea, constipation, somnolence, or insomnia. However, ocular side effects are rarely reported with aripiprazole, with myopia being the most commonly reported. Eight cases of aripiprazole-induced myopia were reported and only two cases of diplopia secondary to aripiprazole use were reported in literature. Aim: We aim to report a case of aripiprazole-induced diplopia in a 28-year-old woman who was treated for depression with psychotic symptoms. Case description: A 28-year-old woman who was a known case of depression with psychotic symptoms was treated with 3 mg oral risperidone but had to be switched to aripiprazole due to hyperprolactinemia. Within 10 days of starting oral aripiprazole at a dose of 10 mg, the patient reported symptoms of double vision and blurring of vision in both eyes. On ophthalmologic evaluation, the patient did not have any refractory error. She did not have signs of any extrapyramidal symptoms, and preliminary neurological examination did not reveal any other abnormalities. Keeping in mind the possibility of the rare side effect of diplopia, she was advised to discontinue aripiprazole. On stopping the drug, the patient reported reduction in symptoms within 5 days with complete resolution in 10 days of stopping aripiprazole. The acute onset of diplopia and resolution of symptoms after stopping the drug correlates strongly with aripiprazole-induced diplopia. Till date, only two such cases were reported. Conclusion: Both the treating psychiatrists and ophthalmologists should be well aware that though rare, diplopia is a possible adverse effect of aripiprazole. Prompt discontinuation can reverse the condition.

  1. Taylor DM. Aripiprazole: a review of its pharmacology and clinical use. Int J Clin Pract 2003;57(1):49–54.
  2. Fleischhacker WW. Aripiprazole. Expert Opin Pharmacother 2005;6(12):2091–2101. DOI: 10.1517/14656566.6.12.2091.
  3. Goodnick PJ, Jerry JM. Aripiprazole: profile on efficacy and safety. Expert Opin Pharmacother 2002;3(12):1773–1781. DOI: 10.1517/14656566.3.12.1773.
  4. Gupta S, Lakshmanan DAM, Khastgir U, et al. Management of antipsychotic-induced hyperprolactinaemia. B J Psych Adv 2017;23(4):278–286. DOI: 10.1192/apt.bp.115.014928.
  5. Abreu T, Pinheiro J. Aripiprazole induced myopia–case report and literature review: Aripiprazole induced myopia. Clin Schizophr Relat Psychoses 2019. DOI: 10.3371/CSRP.TAJP.121218.
  6. Selvi Y, Atli A, Aydin A, et al. Aripiprazole-related acute transient myopia and diplopia: a case report. J Clin Psychopharmacol 2011;31(2):249–250. DOI: 10.1097/JCP.0b013e3182103493.
  7. Atli A, Selvi Y, Yildiz A, et al. Aripiprazole-induced diplopia: a case report. Klinik Psikofarmakol Büteni 2013;23(4):353–356. DOI: 10.5455/bcp.20130303114826.
PDF Share
PDF Share

© Jaypee Brothers Medical Publishers (P) LTD.