All endoscopic procedures demand minimal blood loss during surgery to achieve good visibility which facilitates the speed of surgery. Vasopressin is often used for local infiltration during uterine myomectomy. It has good clinical effects but its systemic absorption may pose significant challenges for the anesthesiologist. It may sometimes lead to lethal complications. The loss of peripheral pulse along with bradycardia, non-measurable blood pressure, and cardiac complications have been reported after intramyometrial injection of vasopressin. Here, we describe a patient with multiple uterine fibroids who developed ventricular tachycardia within 2–3 minutes after intramyometrial infiltration of vasopressin diluted in normal saline. The total dose of vasopressin being 5.36 units (0.067 units/mL) with severe peripheral arterial vasospasm, increased blood pressure, and ventricular tachycardia followed by pulmonary edema. The patient was successfully resuscitated.