Background and objectives: Dyslipidemia is a fairly common occurrence in chronic renal failure (CRF) patients. Cardiovascular mortality in patients with CRF is related to dyslipidemia. This study was done to identify the lipid abnormalities and its significance in CRF patients by comparing with age, sex, and body mass index (BMI) of matched healthy control population. Materials and methods: In this study, 56 cases of CRF were taken and three fasting lipid profiles were estimated. Twentyfive age-, sex-, and BMI-matched healthy population were taken as controls. The data were entered in a master sheet and analyzed statistically. Results: Dyslipidemia is seen in CRF patients. Even though the total cholesterol was high in CRF cases compared with controls, the change was not significant statistically. Triglycerides showed a statistically significant increase in CRF cases. The low-density lipoprotein cholesterol (LDL-C) was elevated in CRF cases but the change was not significant statistically. The high-density lipoprotein cholesterol (HDL-C), on the contrary, showed a statistically significant drop compared with controls. Interpretation and results: Lipid abnormalities are common in CRF. Total cholesterol changes are not statistically significant. Triglycerides shows statistically significant increase in CRF cases when compared with normal. The LDL-C is increased in CRF patients, but it is not statistically significant when compared with controls. The HDL-C shows a statistically significant decrease in CRF patients compared with controls. These lipid abnormalities may be an important contributing factor to the cardiovascular mortality in patients with CRF.