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VOLUME 4 , ISSUE 1 ( January-March, 2018 ) > List of Articles

ORIGINAL ARTICLE

Impact of Levothyroxine Therapy on Lipid Profile Value in Patients with Subclinical Hypothyroidism

Citation Information : Impact of Levothyroxine Therapy on Lipid Profile Value in Patients with Subclinical Hypothyroidism. J Med Sci 2018; 4 (1):10-13.

DOI: 10.5005/jp-journals-10045-0073

License: CC BY-SA 4.0

Published Online: 00-03-2018

Copyright Statement:  Copyright © 2018; Jaypee Brothers Medical Publishers (P) Ltd.


Abstract

Aim: To study the effect of levothyroxine treatment on lipid profile in patients with subclinical hypothyroidism. Materials and methods: This study was a randomized controlled trial, prospective study conducted on 22 cases of subclinical hypothyroidism with 22 controls at Down Town Hospital, Guwahati, Assam, India. Inclusion and exclusion criteria were undertaken. Levothyroxine therapy was given and follow-up was done after 3 months with thyroid and lipid profile tests. Pretreatment and posttreatment values were compared using paired t-test using Statistical Package for the Social Sciences (SPSS), version 19. Results: Statistical significance between pretreatment and posttreatment values was found to be in values of thyroidstimulating hormone (TSH), cholesterol high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, and triglycerides (p < 0.05). There was no significant difference in the pretreatment and posttreatment triiodothyronine (T3) and thyroxine (T4) values. There was mild increase in value of HDL, and significant decrease in value of TSH, cholesterol, very low density lipoprotein (VLDL), and triglycerides. Conclusion: Lipid profiles are altered in patients with subclinical hypothyroidism compared with controls. Levothyroxine therapy has beneficial effect on lipid profile in patients with subclinical hypothyroidism. Clinical significance: Levothyroxine therapy in patients of subclinical hypothyroidism reduces TSH levels and thus prevents conversion to overt hypothyroidism and also reduces cardiac morbidity.


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