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VOLUME 3 , ISSUE 3 ( July-September, 2017 ) > List of Articles
Citation Information : Histopathological Spectrum of Non-neoplastic and Neoplastic Lesions of Thyroid: A 5-year Prospective Study in a Tertiary Care Hospital. J Med Sci 2017; 3 (3):10.5005/jp-journals-10045-0059.
License: CC BY-SA 4.0
Published Online: 01-12-2017
Copyright Statement: Copyright © 2017; The Author(s).
Introduction: Thyroid gland is unique among the endocrine glands in that it can be affected by a wide spectrum of diseases ranging from functional and immunologically mediated enlargements to neoplastic lesions. Thyroid neoplasms represent the most common malignancies of the endocrine system. Aims and objectives: To study the frequency of various thyroid lesions in thyroidectomy specimens and categorize neoplasms based on current World Health Organization (WHO) classification. Materials and methods: All thyroidectomy specimens received in the Department of Pathology, Raja Rajeswari Medical College, Bengaluru, India, for histopathological examination over a period of 5 years, from July 2010 to June 2015, were included in the study. Results: A total of 211 thyroidectomies were examined in the study. The highest incidence of thyroid lesions was seen in the fourth decade (n = 68, 36%) and showed a female predominance (90%). Non-neoplastic lesions accounted for 148 cases (70.1%) and neoplasms accounted for 63 cases (29.9%). The common non-neoplastic lesions were multinodular goiter (37.2%) followed by Hashimoto thyroiditis (35.8%), colloid goiter (16.9%), and adenomatous hyperplasia (5.3%). Benign neoplasms (22.2%) were lower with all cases being follicular adenoma, and malignancies were higher (77.8%) with papillary carcinoma (58.7%) as the most common malignancy in our study. Colloid goiter and multinodular goiter were the common features in peritumoral thyroid tissue, followed by Hashimoto thyroiditis. Conclusion: Thyroid disorders are commonly encountered endocrine diseases. Histopathological examination is the mainstay for definitive diagnosis and management of thyroid neoplasms. Appropriate categorization of neoplasms according to international guidelines is to be followed for diagnostic accuracy.