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VOLUME 2 , ISSUE 2 ( April-June, 2016 ) > List of Articles


Study of Clinical Profile of Community-acquired Pneumonia with Special Reference to C-reactive Protein and Procalcitonin Levels

KC Prajwal, MV Krishna, Sharanappa Patil

DOI: 10.5005/jp-journals-10045-0030

License: NA

Published Online: 01-12-2016

Copyright Statement:  NA



Pneumonia is defined as an infection of the pulmonary parenchyma. Despite being the cause of significant complications and deaths, pneumonia is often wrongly diagnosed, mistreated, and underestimated. The incidence rates are highest in old-aged patients. In the current prospective observational study, we intend to study the utility of procalcitonin (PCT) level and serum C-reactive protein (CRP) level for diagnosing pneumonia.


Prospective observational studies.

Materials and methods

The study was conducted in RajaRajeswari Medical College and Hospital, Bengaluru, during the period extending from June to May 2014. Eighty patients, aged more than 18 years, with diagnosis of pneumonia were included in the study. Serum PCT levels were calculated using BRAHMS PCT Kryptor immunofluorescent assay (Biomerieux, France). Other routine investigations, including CRP, sputum culture, and endotracheal secretions cultures, were done. Chisquare analysis was done to assess its prognostic and diagnostic significance. Data were analysed with Statistical Package for the Social Sciences (version 17.0 for Windows).

Results and conclusion

C-reactive protein was positive in 60 (75%) of the patients, and PCT was positive in 45 (56.25%) patients; 28 patients had PCT levels 0.5 to 1.5 ng/mL, 1 (3.6%) had CRP <6 mg/mL, 27 (96.4%) had CRP >6 mg/mL; 17 patients had PCT values >1.5 ng/mL and CRP was positive in all patients (p < 0.001). Streptococcus pneumonia was the most common and isolated in 8 (10%) patients. C-reactive protein is a useful and better adjuvant in the diagnosis of community-acquired pneumonia (CAP). Positive PCT levels indicate a bacterial etiology for pneumonia. A high PCT level is a poor prognostic indicator and is associated with a higher mortality.

How to cite this article

Prajwal KC, Krishna MV, Patil S. Study of Clinical Profile of Community-acquired Pneumonia with Special Reference to C-reactive Protein and Procalcitonin Levels. J Med Sci 2016;2(2):27-30.

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  1. Practice guidelines for the management of community- acquired pneumonia in adults. Infectious Diseases Society of America. Clin Infect Dis 2000 Aug;31(2:)347-382.
  2. Serological reactions in pneumonia with a non-protein somatic fraction of pneumococcus. J Exp Med 1930 Sep;52(4:)561-571.
  3. Clinical biomarkers in drug discovery and development. Nat Rev Drug Discov 2003 Jul;2(7:)566-580.
  4. The C-reactive protein. J Emerg Med 1999 Nov-Dec;17(6:)1019-1025.
  5. Calcitonin precursors are reliable markers of sepsis in a medical intensive care unit. Crit Care Med 2000 Apr;28(4:)977-983.
  6. Geneva Sepsis Network. Diagnostic value of procalcitonin, interleukin-6, and inter-leukin-8 in critically ill patients admitted with suspected sepsis. Am J Respir Crit Care Med 2001 Aug;164(3:)396-402.
  7. Procalcitonin for early diagnosis and differentiation of SIRS, sepsis, severe sepsis, and septic shock. Intensive Care Med 2000 Mar;26(Suppl 2):S148-S152.
  8. , Clin. Chem. 1993; 39:1953-1959.
  9. Performance of bedside C reactive protein test in the diagnosis of community acquired pneumonia in adults with cough. Am J Med 2004 Apr;116(8:)529-535.
  10. Risk prediction with procalcitonin and clinical rules in community-acquired pneumonia. Ann Emerg Med 2008 Jul;52(1:)48-58.
  11. Usefulness of procalcitonin levels in community-acquired pneumonia according to the patients outcome research team pneumonia severity index. Chest 2005 Oct;128(4:)2223-2229.
  12. Procalcitonin versus C-reactive protein for predicting pneumonia in adults with lower respiratory tract infection in primary care. Br J Gen Pract 2007 Jul;57(540:)555-560.
  13. Diagnostic and prognostic accuracy of clinical and laboratory parameters in community-acquired pneumonia. BMC Infect Dis 2007 Mar;7:10.
  14. Diagnostic and prognostic values of admission procalcitonin levels in community-acquired pneumonia in an intensive care unit. Infection 2005 Aug;33(4:)257-263.
  15. Procalcitonin and C-reactive protein levels in community-acquired pneumonia: correlation with etiology and prognosis. Infection 2000 Mar-Apr;28(2:)68-73.
  16. Procalcitonin predicts patients at low risk of death from community-acquired pneumonia across all CRB-65 classes. Eur Respir J 2008 Feb;31(2:)349-355.
  17. Comparison of procalcitonin and C-reactive protein as markers of sepsis. Crit Care Med 2003 Jun;31(6:)1737-1741.
  18. Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study. BMJ 2013 Apr;346:f2450.
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