Hepatopulmonary syndrome (HPS) is a rare, yet significant, complication of chronic liver disease (CLD) characterized by the triad of liver disease, arterial hypoxemia, and intrapulmonary vascular dilatations (IPVDs). It commonly complicates CLD, leading to significant morbidity and impacting patient prognosis. This case report presents a 56-year-old female diagnosed with decompensated liver cirrhosis (DLC), who exhibited persistent oxygen requirement and orthodeoxia, eventually leading to the diagnosis of HPS.
Dahiya DS, Kichloo A, Shaka H, et al. Hepatopulmonary syndrome: a nationwide analysis of epidemiological trends and outcomes from 2012 to 2018. Gastroenterology Res 2021;14(4):252–258. DOI: 10.14740/gr1448
Bommena S, Gerkin RD, Agarwal S, et al. Diagnosis of hepatopulmonary syndrome in a large integrated health system. Clin Gastroenterol Hepatol 2021;19(11):2370–2378. DOI: 10.1016/j.cgh.2020.09.050
Igata S, Kono Y, Van Houten T, et al. Role of quantitation of saline bubble studies in patients with liver cirrhosis. Ultrasound Med Biol 2023;49(8):1804–1810. DOI: 10.1016/j.ultrasmedbio.2023.04.003
Murphy C, Arad D. Case report: hepatopulmonary syndrome as the first clinical manifestation of cirrhosis in a patient with underlying chronic lung disease. F1000Res 2018;7:1175. DOI: 10.12688/f1000research.15434.2
Gandhi KD, Taweesedt PT, Sharma M, et al. Hepatopulmonary syndrome: an update. World J Hepatol 2021;13(11):1699–1706. DOI: 10.4254/wjh.v13.i11.1699
Chan SKT, Lim ZMJ, Tay SM. Navigating a complicated liver transplant in a patient with severe hepatopulmonary syndrome without extracorporeal membrane oxygenation: a case report. Singapore Med J 2023;64(8):538–542. DOI: 10.11622/smedj.2022002
