Objective: Synovial sarcoma (SS) is a rare mesenchymal neoplasm that can occur in various sites with a morphological spectrum, and it has the ability to mimic other malignant neoplasms.
Materials and methods: For this study, 15 cases of SS reported over a period of 5 years were analyzed.
Results: The most common site of occurrence was the thorax. Monophasic histology was common in 60% of the cases taken for this study. The differential diagnosis varied depending upon the site and histology. The common aspects shared by all the cases of SS were variable immunohistochemistry (IHC) marker expression of epithelial membrane antigen (EMA), cytokeratin, S100, cluster of differentiation 99 (CD99), B-cell leukemia/lymphoma 2 protein (Bcl-2), and transducin-like enhancer of split-1 (TLE1), and being consistently negative for CD34.
Conclusion: This study highlights the importance of knowledge as well as awareness about various histomorphological spectrums of SS in different sites.
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